General Articles of Interest | Measurement of Cell Proliferation | HIV/AIDS T-Cell Kinetics and Lifespan | Measurement of Protein Synthesis and Degradation | Fuel Selection/Carbohydrate, Lipid and Cholesterol Metabolism | Advances in Mass Spectrometry Applications | Toxicology

General Articles of Interest

Measurement of Brain Microglial Proliferation Rates In Vivo in Response to Neuroinflammatory Stimuli: Application to Drug Discovery
J of Neurosci Res. 2007 Aug; 85(11):2374-84.

Measurement of cell proliferation by heavy water labeling.
Nature Protocols. 2007. 2(12):3045-57.

Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography / pyrolysis / isotope ratio / mass spectrometric analysis
Nature Protocols. 2007. 2(12): 3058-62.

Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery.
J Pharmacol Exp Ther. 2008 Apr; 325(1):1-9

A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes.
J Lipid Res. 2008 Dec; 49(12):2657-63.

Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups.
Int J Obes (Lond). 2008 Apr; 32(4):648-57

Measurement of pancreatic islet cell proliferation by heavy water labeling.
Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1459-64.

Measurement of liver collagen synthesis by heavy water labeling: effects of pro-fibrotic toxicants and anti-fibrotic interventions.
Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1695-705.

Stabilization of Hyperdynamic Microtubules Is Neuroprotective in Amyotrophic Lateral Sclerosis.
J Biol Chem. 2007 Aug 10;282(32):23465-72

Whole-Body Glycolysis Measured by the Deuterated-Glucose Disposal Test Correlates Highly With Insulin Resistance In Vivo Diabetes Care.
Diabetes Care, 2007;30(5):1143-1149

Emerging applications of kinetic biomarkers in pre-clinical and clinical drug development.
Curr Opin Drug Discov Devel, 2005. 8(1): p. 115-26.

Metabolic Syndrome: The making of a new disease
PharmExec.com 2004

Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development.
Curr Opin Mol Ther 2004;6:249-64.

In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research.
Annu Rev Nutr 2003;23:379-402.

New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping.
Metab Eng 2004;6:85-100.

Back To Top

Measurement of Cell Proliferation

Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding.
Am J Physiol Endocrinol Metab, 2005. 288(5): p. E965-72.

In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis.
Biochem Biophys Res Commun, 2005. 331(1): p. 203-9.

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
J Clinical Investigation 2005;115:755-64.

Dynamics of keratinocytes in vivo using ²H₂O labeling: a sensitive marker of epidermal proliferation state.
J Invest Dermatol 2004;123:530-6.

Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans.
Breast Cancer Research and Treatment 2005;89:257-264

Measurement in vivo of proliferation rates of slow turnover cells by ²H₂O labeling of the deoxyribose moiety of DNA.
Proc Natl Acad Sci U S A 2002;99:15345-50.

Advances in the Stable Isotope-Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation
Anal Biochem 2001;298:189

Measurement Of Cell Proliferation By Labeling Of DNA With Stable Isotope-Labeled Glucose: Studies In Vitro, In Animals, And In Humans
Proc Natl Acad Sci U S A. 1998;95:708

Factors Influencing T-Cell Turnover In HIV-1–Seropositive Patients
J Clin Invest. 2000;105:R1

Back To Top

HIV/AIDS T-Cell Kinetics and Lifespan

CD4+ T Cell Kinetics and Activation in Human Immunodeficiency Virus-Infected Patients who Remain Viremic Despite Long-Term Treatment with Protease Inhibitor-Based Therapy
J Infect Dis. 2002;185:315

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Anti-retroviral Therapy
J Exp Med. 2001;194:1277

Measurement Of T-Cell Kinetics: Recent Methodologic Advances
Immunol Today. 1999;20:438

Poor CD4 T Cell Restoration After Suppression Of HIV-1 Replication May Reflect Lower Thymic Function
AIDS. 2001;15:1749

Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans
Nat Med. 1999 ;5:83

Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans
Nat Med. 1999;5:27
Related Article: Unraveling the strands of HIV's web Nat Med. 1999; 5:1

Back To Top

Measurement of Protein Synthesis and Degradation

In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water: effect of taxanes.
J Biol Chem 2004.

Effect of Ibuprofen and Acetaminophen on Post-Exercise Muscle Protein Synthesis
Am J Physiol Endocrinol Metab 2002;282:E551

Measuring Protein Synthesis by Mass Isotopomer Distribution Analysis (MIDA)
Anal Biochem. 1999;267:1

Back To Top

Fuel Selection / Carbohydrate, Lipid and Cholesterol Metabolism

Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis
J Biol Chem, 280(27): p. 25396-402

The Contribution Of Newly Synthesized Cholesterol To Bile Salt Synthesis In Rats Quantified By Mass Isotopomer Distribution Analysis
Biochim Biophys Acta. 2000;1483:343

Effects Of Nicotinic Acid On Fatty Acid Kinetics, Fuel Selection, And Pathways Of Glucose Production In Women
Am J Physiol Endocrinol Metab. 2000;279:E50

De Novo Lipogenesis, Lipid Kinetics, And Whole-Body Lipid Balances In Humans After Acute Alcohol Consumption
Am J Clin Nutr 1999;70:928

Effects Of A Low-Fat, High-Carbohydrate Diet On VLDL-triglyceride Assembly, Production, And Clearance
J Clin Invest. 1999;104:1087

Carbohydrate-Induced Hyper-triacylglycerolemia: Historical perspective and review of biological mechanisms
Am J Clin Nutr , 2000;71:412

Effect of Dietary Energy Restriction on Glucose Production and Substrate Utilization in Type 2 Diabetes
Diabetes. 2000;49:1691

A Deficiency of Microsomal Triglyceride Transfer Protein Reduces Apolipoprotein B Secretion*
J Biol Chem. 2000;275:7515

Relationship Between Carbohydrate-Induced Hyper-triglyceridemia And Fatty Acid Synthesis In Lean And Obese Subjects
J Lipid Res 2000;41:595

Back To Top

Advances in Mass Spectrometry Applications

Elimination of the Concentration Dependence in Mass Isotopomer Abundance Mass Spectrometry of Methyl Palmitate Using Metastable Atom Bombardment
J Am Soc Mass Spectrom 2001;12:754

Mass Isotopomer Distribution Analysis at Eight Years: Theoretical, Analytic, and Experimental Considerations
Am J Physiol. 1999;276:E1146

Molecular Ion Fragmentation and its Effects on Mass Isotopomer Abundances of Fatty Acid Methyl Esters Ionized by Electron Impact
Am Soc Mass Spectrom. 1999;10:430

Back To Top

Toxicology

Stable isotopes, mass spectrometry, and molecular fluxes: Applications to toxicology
Journal of Pharmacological and Toxicological Methods 2005

Back To Top