Protein and Proteome Dynamics

1. Brain chemistry
   1. Cargo kinetics (axonal transport)
   2. Amyloid beta/amyloid plaque turnover
   3. Huntington turnover, prion turnover, etc.
2. Peripheral disease targets
   1. Fibrogenesis (collagen turnover)
   2. Muscle proteins
   3. Skin keratin
   4. Hormone and cytokine secretion
3. Dynamic proteomics (global protein turnover)

Deuteron Fluxes for Pathway Dynamics

1. Cell kinetics
   • Cancer cells (liquid, solid tumors)
   • Neurogenesis
   • Immunocyte dynamics (T cells, macrophages,e tc.)
   • Pancreatic beta cell proliferation
   • Adipogenesis
   • Angiogenesis, etc.
2. Histokinetics
   • Prostate epithelial cells
   • Mammary cells
   • Cancer cells
   • Muscle satellite cells, etc.
3. Flux distributions/dynamic fingerprinting
   • Ligand selectivity
   • Adipose fingerprinting
   • Metabolome dynamics, etc.
4. Biosynthetic pathways
   • Lipid synthesis (dynamic lipomics)
   • Carbohydrate dynamics
   • Glcosaminoglycans, etc.