 |
 |
 |
|
 |
 |
 |
 |
 |
 |
 |
 |
 |
|||
 |
|
Publications
General Articles of Interest | Measurement of Cell Proliferation | HIV/AIDS T-Cell Kinetics and Lifespan | Measurement of Protein Synthesis and Degradation | Fuel Selection/Carbohydrate, Lipid and Cholesterol Metabolism | Advances in Mass Spectrometry Applications | Toxicology  |
||||
 |
Measurement of Brain Microglial Proliferation Rates In Vivo in Response to Neuroinflammatory Stimuli: Application to Drug Discovery J of Neurosci Res. 2007 Aug; 85(11):2374-84. |
|||
|
Measurement of cell proliferation by heavy water labeling. Nature Protocols. 2007. 2(12):3045-57. |
|||
|
Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography|pyrolysis|isotope ratio–mass spectrometric analysis Nature Protocols. 2007. 2(12): 3058-62. |
|||
|
Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery. J Pharmacol Exp Ther. 2008 Apr; 325(1):1-9 |
|||
|
A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes. J Lipid Res. 2008 Dec; 49(12):2657-63. |
|||
|
Time course and dynamics of adipose tissue development in obese and lean Zuck rat pups. Int J Obes (Lond). 2008 Apr; 32(4):648-57 |
|||
|
Measurement of pancreatic islet cell proliferation by heavy water labeling. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1459-64. |
|||
|
Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1695-705. |
|||
|
Stabilization of Hyperdynamic Microtubules Is Neuroprotective in Amyotrophic Lateral Sclerosis. J Biol Chem. 2007 Aug 10;282(32):23465-72 |
|||
|
Whole-Body Glycolysis Measured by the Deuterated-Glucose Disposal Test
Correlates Highly With Insulin Resistance In Vivo
Diabetes Care. Diabetes Care, 2007;30(5):1143-1149 |
|||
|
Emerging applications of kinetic biomarkers in preclinical and clinical drug development. Curr Opin Drug Discov Devel, 2005. 8(1): p. 115-26. |
|||
|
Metabolic Syndrome: The making of a new disease PharmExec.com 2004 |
|||
|
Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development. Curr Opin Mol Ther 2004;6:249-64. |
|||
|
In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research. Annu Rev Nutr 2003;23:379-402. |
|||
|
New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping. Metab Eng 2004;6:85-100. |
|||
 Measurement of Cell Proliferation |
||||
| |
Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding. Am J Physiol Endocrinol Metab, 2005. 288(5): p. E965-72. |
|||
| |
In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis. Biochem Biophys Res Commun, 2005. 331(1): p. 203-9. |
|||
| |
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells J Clinical Investigation 2005;115:755-64. |
|||
| |
Dynamics of keratinocytes in vivo using 2H2O labeling: a sensitive marker of epidermal proliferation state. J Invest Dermatol 2004;123:530-6. |
|||
| |
Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans. Breast Cancer Research and Treatment 2005;89:257-264 |
|||
| |
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A 2002;99:15345-50. |
|||
| |
Advances in the Stable Isotope-Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation Anal Biochem 2001;298:189 |
|||
| |
Measurement Of Cell Proliferation By Labeling Of DNA With Stable Isotope-Labeled Glucose: Studies In Vitro, In Animals, And In Humans Proc Natl Acad Sci U S A. 1998;95:708 |
|||
| |
Factors Influencing T-Cell Turnover In HIV-1–Seropositive Patients J Clin Invest. 2000;105:R1 |
|||
HIV/AIDS T-Cell Kinetics and Lifespan |
||||
| |
CD4+ T Cell Kinetics and Activation in Human Immunodeficiency Virus-Infected Patients who Remain Viremic Despite Long-Term Treatment with Protease Inhibitor-Based Therapy J Infect Dis. 2002;185:315 |
|||
| |
Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy J Exp Med. 2001;194:1277 |
|||
| |
Measurement Of T-Cell Kinetics: Recent Methodologic Advances Immunol Today. 1999;20:438 |
|||
| |
Poor CD4 T Cell Restoration After Suppression Of HIV-1 Replication May Reflect Lower Thymic Function AIDS. 2001;15:1749 |
|||
| |
Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans Nat Med. 1999 ;5:83 |
|||
| |
Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans Nat Med. 1999;5:27 Related Article: Unraveling the strands of HIV's web Nat Med. 1999; 5:1 |
|||
Measurement of Protein Synthesis and Degradation |
||||
|
In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water: effect of taxanes. J Biol Chem 2004. |
|||
|
Effect of Ibuprofen and Acetaminophen on Post Exercise Muscle Protein Synthesis Am J Physiol Endocrinol Metab 2002;282:E551 |
|||
|
Measuring Protein Synthesis by Mass Isotopomer Distribution Analysis (MIDA) Anal Biochem. 1999;267:1 |
|||
Fuel Selection/Carbohydrate, Lipid and Cholesterol Metabolism |
||||
| |
Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis J Biol Chem, 280(27): p. 25396-402 |
|||
| |
The Contribution Of Newly Synthesized Cholesterol To Bile Salt Synthesis In Rats Quantified By Mass Isotopomer Distribution Analysis Biochim Biophys Acta. 2000;1483:343 |
|||
| |
Effects Of Nicotinic Acid On Fatty Acid Kinetics, Fuel Selection, And Pathways Of Glucose Production In Women Am J Physiol Endocrinol Metab. 2000;279:E50 |
|||
| |
De Novo Lipogenesis, Lipid Kinetics, And Whole-Body Lipid Balances In Humans After Acute Alcohol Consumption Am J Clin Nutr 1999;70:928 |
|||
| |
Effects Of A Low-Fat, High-Carbohydrate Diet On VLDL-triglyceride Assembly, Production, And Clearance J Clin Invest. 1999;104:1087 |
|||
| |
Carbohydrate-Induced Hypertriacylglycerolemia: Historical perspective and review of biological mechanisms Am J Clin Nutr , 2000;71:412 |
|||
| |
Effect of Dietary Energy Restriction on Glucose Production and Substrate Utilization in Type 2 Diabetes Diabetes. 2000;49:1691 |
|||
| |
A Deficiency of Microsomal Triglyceride Transfer Protein Reduces Apolipoprotein B Secretion* J Biol Chem. 2000;275:7515 |
|||
| |
Relationship Between Carbohydrate-Induced Hypertriglyceridemia And Fatty Acid Synthesis In Lean And Obese Subjects J Lipid Res 2000;41:595 |
|||
Advances in Mass Spectrometry Applications |
||||
| |
Elimination of the Concentration Dependence in Mass Isotopomer Abundance Mass Spectrometry of Methyl Palmitate Using Metastable Atom Bombardment J Am Soc Mass Spectrom 2001;12:754 |
|||
| |
Mass Isotopomer Distribution Analysis at Eight Years: Theoretical, Analytic, and Experimental Considerations Am J Physiol. 1999;276:E1146 |
|||
| |
Molecular Ion Fragmentation and its Effects on Mass Isotopomer Abundances of Fatty Acid Methyl Esters Ionized by Electron Imact Am Soc Mass Spectrom. 1999;10:430
|
|||
Toxicology |
||||
| |
Stable isotopes, mass spectrometry, and molecular fluxes:
Applications to toxicology Journal of Pharmacological and Toxicological Methods 2005
|
|||