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Publications
General Articles of Interest | Measurement of Cell Proliferation | HIV/AIDS T-Cell Kinetics and Lifespan | Measurement of Protein Synthesis and Degradation | Fuel Selection/Carbohydrate, Lipid and Cholesterol Metabolism | Advances in Mass Spectrometry Applications | Toxicology  |
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Whole-Body Glycolysis Measured by the Deuterated-Glucose Disposal Test
Correlates Highly With Insulin Resistance In Vivo
Diabetes Care. Diabetes Care, 2007;30(5):1143-1149 |
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Emerging applications of kinetic biomarkers in preclinical and clinical drug development. Curr Opin Drug Discov Devel, 2005. 8(1): p. 115-26. |
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Metabolic Syndrome: The making of a new disease PharmExec.com 2004 |
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Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development. Curr Opin Mol Ther 2004;6:249-64. |
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In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research. Annu Rev Nutr 2003;23:379-402. |
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New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping. Metab Eng 2004;6:85-100. |
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 Measurement of Cell Proliferation |
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Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding. Am J Physiol Endocrinol Metab, 2005. 288(5): p. E965-72. |
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In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis. Biochem Biophys Res Commun, 2005. 331(1): p. 203-9. |
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In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells J Clinical Investigation 2005;115:755-64. |
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Dynamics of keratinocytes in vivo using 2H2O labeling: a sensitive marker of epidermal proliferation state. J Invest Dermatol 2004;123:530-6. |
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Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans. Breast Cancer Research and Treatment 2005;89:257-264 |
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Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A 2002;99:15345-50. |
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Advances in the Stable Isotope-Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation Anal Biochem 2001;298:189 |
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Measurement Of Cell Proliferation By Labeling Of DNA With Stable Isotope-Labeled Glucose: Studies In Vitro, In Animals, And In Humans Proc Natl Acad Sci U S A. 1998;95:708 |
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Factors Influencing T-Cell Turnover In HIV-1–Seropositive Patients J Clin Invest. 2000;105:R1 |
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HIV/AIDS T-Cell Kinetics and Lifespan |
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CD4+ T Cell Kinetics and Activation in Human Immunodeficiency Virus-Infected Patients who Remain Viremic Despite Long-Term Treatment with Protease Inhibitor-Based Therapy J Infect Dis. 2002;185:315 |
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Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy J Exp Med. 2001;194:1277 |
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Measurement Of T-Cell Kinetics: Recent Methodologic Advances Immunol Today. 1999;20:438 |
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Poor CD4 T Cell Restoration After Suppression Of HIV-1 Replication May Reflect Lower Thymic Function AIDS. 2001;15:1749 |
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Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans Nat Med. 1999 ;5:83 |
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Directly Measured Kinetics of Circulating T Lymphocytes in Normal and HIV-1-Infected Humans - Related Article Nat Med. 1999;5:27 |
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Measurement of Protein Synthesis and Degradation |
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In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water: effect of taxanes. J Biol Chem 2004. |
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Effect of Ibuprofen and Acetaminophen on Post Exercise Muscle Protein Synthesis Am J Physiol Endocrinol Metab 2002;282:E551 |
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Measuring Protein Synthesis by Mass Isotopomer Distribution Analysis (MIDA) Anal Biochem. 1999;267:1 |
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Fuel Selection/Carbohydrate, Lipid and Cholesterol Metabolism |
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Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis J Biol Chem, 280(27): p. 25396-402 |
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The Contribution Of Newly Synthesized Cholesterol To Bile Salt Synthesis In Rats Quantified By Mass Isotopomer Distribution Analysis Biochim Biophys Acta. 2000;1483:343 |
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Effects Of Nicotinic Acid On Fatty Acid Kinetics, Fuel Selection, And Pathways Of Glucose Production In Women Am J Physiol Endocrinol Metab. 2000;279:E50 |
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De Novo Lipogenesis, Lipid Kinetics, And Whole-Body Lipid Balances In Humans After Acute Alcohol Consumption Am J Clin Nutr 1999;70:928 |
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Effects Of A Low-Fat, High-Carbohydrate Diet On VLDL-triglyceride Assembly, Production, And Clearance J Clin Invest. 1999;104:1087 |
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Carbohydrate-Induced Hypertriacylglycerolemia: Historical perspective and review of biological mechanisms Am J Clin Nutr , 2000;71:412 |
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Effect of Dietary Energy Restriction on Glucose Production and Substrate Utilization in Type 2 Diabetes Diabetes. 2000;49:1691 |
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A Deficiency of Microsomal Triglyceride Transfer Protein Reduces Apolipoprotein B Secretion* J Biol Chem. 2000;275:7515 |
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Relationship Between Carbohydrate-Induced Hypertriglyceridemia And Fatty Acid Synthesis In Lean And Obese Subjects J Lipid Res 2000;41:595 |
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Advances in Mass Spectrometry Applications |
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Elimination of the Concentration Dependence in Mass Isotopomer Abundance Mass Spectrometry of Methyl Palmitate Using Metastable Atom Bombardment J Am Soc Mass Spectrom 2001;12:754 |
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Mass Isotopomer Distribution Analysis at Eight Years: Theoretical, Analytic, and Experimental Considerations Am J Physiol. 1999;276:E1146 |
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Molecular Ion Fragmentation and its Effects on Mass Isotopomer Abundances of Fatty Acid Methyl Esters Ionized by Electron Imact Am Soc Mass Spectrom. 1999;10:430
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Toxicology |
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Stable isotopes, mass spectrometry, and molecular fluxes:
Applications to toxicology Journal of Pharmacological and Toxicological Methods 2005
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