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Key articles and publications by KineMed scientists and others that directly relate to KineMed’s platform and development programs.


Circulating Protein Synthesis Rates Reveal Skeletal Muscle Proteome Dynamics
Shankaran M, King CL, Angel TE, Holmes WE, Li KW, Colangelo M, Price JC, Turner SM, Bell C, Hamilton KL, Miller BF, Hellerstein MK

J Clin Invest. 2016 Jan 4;126(1):288-302. doi: 10.1172/JCI79639. Epub 2015 Dec 14.


Dynamic Proteomics: In Vivo Proteome-Wide Measurement of Protein Kinetics using Metabolic Labeling

W.E. Holmes, T.E. Angel, K.W. Li, M.K. Hellerstein

2015;561:219-76. doi: 10.1016/bs.mie.2015.05.018. Epub 2015 Jul 17.

© 2015 Elsevier Inc. All rights reserved

Turnover Rates of Hepatic Collagen and Circulating Collagen-Associated Proteins in Humans with Chronic Liver Disease

Decaris ML, Emson CL, Li K, Gatmaitan M, Luo F, Cattin J, Nakamura C, Holmes WE, Angel TE, Peters MG, Turner SM, Hellerstein MK.

PLoS One. 2015 Apr 24;10(4):e0123311. doi: 10.1371/journal.pone.0123311. eCollection 2015.
PMID: 25909381

PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth

Abu Aboud O, Donohoe D, Bultman S, Fitch M, Riiff T, Hellerstein M, Weiss RH.

Am J Physiol Cell Physiol. 2015 Mar 25:ajpcell.00322.2014. doi: 10.1152/ajpcell.00322.2014. [Epub ahead of print]
PMID: 25810260 

In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans

Allister CA, Liu LF, Lamendola CA, Craig CM, Cushman SW, Hellerstein MK, McLaughlin TL.

J Lipid Res. 2015 Feb;56(2):435-9. doi: 10.1194/jlr.M052860. Epub 2014 Nov 23.
PMID: 25418322 


Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib

Charles-Schoeman C, Fleischmann R, Davignon J, Schwartz H, Turner S, Beysen C, Milad M, Hellerstein M, Luo Z, Kaplan I, Riese R, Zuckerman A, McInnes IB.

Arthritis Rheumatol. 2014 Dec 2. doi: 10.1002/art.38974. [Epub ahead of print]
PMID: 25470338

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

Griffith DA, Kung DW, Esler WP, Amor PA, Bagley SW, Beysen C, Carvajal-Gonzalez S, Doran SD, Limberakis C, Mathiowetz AM, McPherson RK, Price DA, Ravussin E, Sonnenberg GE, Southers JA, Sweet LJ, Turner SM, Vajdos FF

2014 Nov 25. [Epub ahead of print]

PMID: 25423286

Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate calorie restriction in adult mice

Thompson AC, Bruss MD, Nag N, Kharitonenkov A, Adams AC, Hellerstein MK

2014 Nov 4;9(11):e111418. doi: 10.1371/journal.pone.0111418. eCollection 2014.

PMID: 25369265

Treatment of diabetic rats with insulin or a synthetic insulin receptor agonist peptide leads to divergent metabolic responses 

Kinetics of precursor labeling in SILAC experiments

Anal. Chem.Publication Date (Web): October 9, 2014 (Article)
DOI: 10.1021/ac503067a

Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans
Richard V. Clark, Ann C. Walker, Robin L. O'Connor-Semmes, Michael S. Leonard, Ram R. Miller, Stephen A. Stimpson, Scott M. Turner, Eric Ravussin, William T. Cefalu, Marc K. Hellerstein and William J. Evans
J Appl Physiol 116:1605-1613, 2014. First published 24 April 2014;

Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease

Guin S, Pollard C, Ru Y, Ritterson Lew C, Duex JE, Dancik G, Owens C, Spencer A, Knight S, Holemon H, Gupta S, Hansel D, Hellerstein M, Lorkiewicz P, Lane AN, Fan TW, Theodorescu D.

J Natl Cancer Inst. 2014 Apr 3;106(5). pii: dju062. doi: 10.1093/jnci/dju062.
PMID: 24700805 


Proteomic Analysis of Altered Extracellular Matrix Turnover in Bleomycin-induced Pulmonary Fibrosis
Martin L. Decaris, Michelle Gatmaitan, Simplicia FlorCruz, Flora Luo, Kelvin Li,
William E. Holmes, Marc K. Hellerstein, Scott M. Turner, and Claire L. Emson

2014 by The American Society for Biochemistry and Molecular Biology, Inc.
This paper is available on line at http://www.mcponline.org

Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training
Rebecca L. Scalzo, Garrett L. Peltonen, Scott E. Binns, Mahalakshmi Shankaran,
Gregory R. Giordano, Dylan A. Hartley, Anna L. Klochak, Mark C. Lonac,
Hunter L. R. Paris, Steve E. Szallar, Lacey M. Wood, Frederick F. Peelor, III,
William E. Holmes, Marc K. Hellerstein, Christopher Bell, Karyn L. Hamilton,
and Benjamin F. Miller

The FASEB Journal article fj.13-246595. Published online March 5, 2014.



SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E.

Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013.
PMID: 24315375 

Extracellular matrix proteins: A positive feedback loop in lung fibrosis?

Blaauboer ME, Boeijen FR, Emson CL, Turner SM, Zandieh-Doulabi B, Hanemaaijer R, Smit TH, Stoop R, Everts V.

Matrix Biol. 2013 Nov 27. pii: S0945-053X(13)00151-0. doi: 10.1016/j.matbio.2013.11.002. [Epub ahead of print]
PMID  24291458

Adipose weight gain during chronic insulin treatment of mice results from changes in lipid storage without affecting de novo synthesis of palmitate
Frikke-Schmidt H, Pedersen TÅ, Fledelius C, Olsen GS, Hellerstein M.

PLoS One. 2013 Sep 17;8(9):e76060. doi: 10.1371/journal.pone.0076060. eCollection 2013.
PMID: 24069458 

Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D3-creatine dilution method

Stephen A. Stimpson, Michael S. Leonard, Lisa G. Clifton, James C. Poole, Scott M. Turner, Todd W. Shearer, Katja S. Remlinger, et al.

J Cachexia Sarcopenia Muscle (2013) 4:217-223
DOI 10.1007/s13539-013-0110-1

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1

Holleboom AG, Jakulj L, Franssen R, Decaris J, Vergeer M, Koetsveld J, Luchoomun J, Glass A, Hellerstein MK, Kastelein JJ, Hovingh GK, Kuivenhoven JA, Groen AK, Turner SM, Stroes ES 

J Lipid Res. 2013 May 6. [Epub ahead of print] 

A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis

Claire L Emson, Sarah Fitzmaurice, Glen Lindwall, Kelvin W Li, Marc K Hellerstein, Howard I Maibach, Wilson Liao and Scott M Turner

Emson et al. Clinical and Translational Medicine 2013, 2:12


Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways

Marjolein E. Blaauboera, Claire L. Emsonc, Lars Verschurend, Marjan van Erkd, Scott M. Turner, Vincent Evertsb, Roeland Hanemaaijera, Reinout Stoopa

Matrix Biology, Available online 3 May 2013

Apolipoprotein M promotes mobilization of cellular cholesterol in vivo

Elsøe S, Christoffersen C, Luchoomun J, Turner S, Nielsen LB
Biochim Biophys Acta. 2013 Apr 21;1831(7):1287-1292. doi: 10.1016/j.bbalip.2013.04.009. [Epub ahead of print]

Hepatic glucose sensing is required to preserve β cell glucose competence

Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B
J Clin Invest. 2013 Apr 1;123(4):1662-76. doi: 10.1172/JCI65538. Epub 2013 Mar 15.


The effect of long term calorie restriction on in vivo hepatic proteostatis: a novel combination of dynamic and quantitative proteomics

Price JC, Khambatta CF, Li KW, Bruss MD, Shankaran M, Dalidd M, Floreani NA, Roberts LS, Turner SM, Holmes WE, Hellerstein MK

Mol Cell Proteomics. 2012 Dec;11(12):1801-14. doi: 10.1074/mcp.M112.021204. Epub 2012 Sep 13.

Plasma plant sterols serve as poor markers of cholesterol absorption in man

Jakulj L, Mohammed H, van Dijk TH, Boer T, Turner S, Groen AK, Vissers MN, Stroes ES
J Lipid Res. 2013 Apr;54(4):1144-50. doi: 10.1194/jlr.P031021. Epub 2012 Nov 25. PMID: 23178226 [PubMed - in process]

Measurement of Reverse Cholesterol Transport Pathways in Humans: In Vivo Rates of Free Cholesterol Efflux, Esterification, and Excretion

Scott Turner, PhD; Jason Voogt, PhD; Michael Davidson, MD; Alex Glass, PhD; Salena Killion, MPH; Julie Decaris, BS; Hussein Mohammed, BS; Kaori Minehira, PhD; Drina Boban, MS; Elizabeth Murphy, MD, DPhil; Jayraz Luchoomun, PhD; Mohamad Awada, PhD; Richard Neese, PhD; Marc Hellerstein, MD, PhD

J Am Heart Assoc. August 17, 2012; 1: e001826 doi: 10.1161/​JAHA 112.001826


Regional cell proliferation in microdissected human prostate specimens after heavy water labeling in vivo: correlation with prostate epithelial cells isolated from seminal fluid

Hayes GM, Simko J, Holochwost D, Kuchinsky K, Busch R, Misell L, Murphy EJ, Carroll P, Chan J, Shinohara K, Hellerstein MK

Clin Cancer Res. 2012 Jun 15;18(12):3250-60. doi: 10.1158/1078-0432.CCR-11-2988. Epub 2012 May 2.

Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

Beysen C, Murphy EJ, Deines K, Chan M, Tsang E, Glass A, Turner SM, Protasio J, Riiff T, Hellerstein MK

Diabetologia. 2012 Feb;55(2):432-42. doi: 10.1007/s00125-011-2382-3. Epub 2011 Dec 2.

Hydrophobic amino acids in the hinge region of the 5a apolipoprotein mimetic peptide are essential for promoting cholesterol efflux by the abca1 transporter

Sviridov DO, Andrianov AM, Anishchenko IV, Stonik JA, Amar MJ, Turner S, Remaley AT

The Journal of pharmacology and experimental therapeutics. 2012

Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-d3) dilution in rats

Stimpson SA, Turner SM, Clifton LG, Poole JC, Mohammed HA, Shearer TW, Waitt GM, Hagerty LL, Remlinger KS, Hellerstein MK, Evans WJ
J Appl Physiol. 2012;112:1940-1948

Measurement of human plasma proteome dynamics with (2)h(2)o and liquid chromatography tandem mass spectrometry

Price JC, Holmes WE, Li KW, Floreani NA, Neese RA, Turner SM, Hellerstein MK
Analytical biochemistry. 2012;420:73-83


Intra-clonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells

Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N

Mol Med. 2011 Sep 23. doi: 10.2119/molmed.2011.00360.

PMID: 21968788

Measurement of human plasma proteome dynamics with (2)H(2)O and liquid chromatography tandem mass spectrometry

Price JC, Holmes WE, Li KW, Floreani NA, Neese RA, Turner SM, Hellerstein MK

Anal Biochem. 2011 Sep 14

PMID: 21964502

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

Ahmadian M, Abbott MJ, Tang T, Hudak CS, Kim Y, Bruss M, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Wang Y, Duncan RE, Kang C, Sul HS

Cell Metab. 2011 Jun 8;13(6):739-48.

PMID: 21641555  

Deuterium and neutrophil kinetics

Li KW, Turner SM, Emson CL, Hellerstein MK, Dale DC

Blood. 2011 Jun 2;117(22):6052-3; author reply 6053-4. No abstract available.

PMID: 21636721

Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by protein supplementation

Robinson MM, Turner SM, Hellerstein MK, Hamilton KL, Miller BF

FASEB J. 2011 Sep;25(9):3240-9. Epub 2011 May 25.

PMID: 21613572

The effects of physiological adaptations to calorie restriction on global cell proliferation rates

Bruss MD, Thompson AC, Aggarwal I, Khambatta CF, Hellerstein MK

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E735-45. Epub 2011 Feb 1

PMID: 21285400

A dual sugar challenge test for lipogenic sensitivity to dietary fructose

Hudgins LC, Parker TS, Levine DM, Hellerstein MK

J Clin Endocrinol Metab. 2011 Mar;96(3):861-8.

Epub 2011 Jan 20

5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice

Amar MJ, D'Souza W, Turner S, Demosky S, Sviridov D, Stonik J, Luchoomun J, Voogt J, Hellerstein M, Sviridov D, Remaley AT

J Pharmacol Exp Ther. 2010 Aug;334(2):634-41

Epub 2010 May 19.


Changes in Microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

Neuroscience. 2010 Jun 16; 168 (1)167-178. Epub 2010 Mar 21.

Fuel Selection / Carbohydrate, Lipid and Cholesterol Metabolism: 5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice

J Pharmacol Exp Ther. 2010 Aug; 334(2):634-41. Epub 2010 May 19.


A stable isotope method for the simultaneous measurement of matrix synthesis and cell proliferation in articular cartilage in vivo

Osteoarthritis Cartilage. 2009; 17(7):923-32

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